发表论文：#共同一作，*通讯作者

1. Xin-Xin Yu#; Xin Wang#, Liu Yang, Mao-Yang He, Xi Wang, Yi-Ning Wang, Ke-Ran Li, and Cheng-Ran Xu*; Reconstructing human pancreatic gene networks enhances stem cell-derived β-cell induction, Developmental Cell, 2026.  

2. Li Yang#, Yu Zhang#, Xin-Xin Yu#, Yu-Heng Zhou#, Shuang He, Liu Yang, Tong-Yun Mao, Jun-Ge Yang, Ying Wu, Qi-Qi Zheng, and Cheng-Ran Xu*; Hepatocyte metabolic adaptations during pregnancy and lactation, Cell, 2025.

3. Xin-Xin Yu; Peng Peng, Chen-Tao Jin, Mao-Yang He, Shuang He, Liu Yang, Xi Wang, Jia-Xi Zheng, Jie Gao, and Cheng-Ran Xu*; Comprehensive characterization of bihormonal cells and endocrine cell lineages in mammalian pancreatic islets, Advanced Science, 2025.

4. Liu Yang#, Xin-Xin Yu#, Xin Wang, Chen-Tao Jin, and Cheng-Ran Xu*; The expression order determines the pioneer functions of Ngn3 and NeuroD1 in pancreatic endocrine differentiation, Science Advances, 2025.

5. Xin-Xin Yu#; Wei-Lin Qiu#; Liu Yang#; Yan-Chun Wang#; Mao-Yang He; Dan Wang; Yu Zhang; Lin-Chen Li; Jing Zhang; Yi Wang; Cheng-Ran Xu*; Sequential progenitor states landmark the generation of pancreatic endocrine lineages in mice and humans, Cell Research, 2021.

6. Xin-Xin Yu; Cheng-Ran Xu*; Understanding generation and regeneration of pancreatic β cells from a single-cell perspective, Development, 2020.

7. Xin-Xin Yu#; Wei-Lin Qiu#; Liu Yang; Yu Zhang; Mao-Yang He; Lin-Chen Li; Cheng-Ran Xu*; Defining multistep cell fate decision pathways during pancreatic development at single-cell resolution, The EMBO journal, 2019.

8. Xin-Xin Yu#; Wei-Lin Qiu#; Liu Yang; Lin-Chen Li; Yu-Wei Zhang; Cheng-Ran Xu*; Dynamics of chromatin marks and the role of JMJD3 during pancreatic endocrine cell fate commitment, Development, 2018.

9. Lin-Chen Li#; Xin-Xin Yu#; Yu-Wei Zhang#; Ye Feng#; Wei-Lin Qiu#; Cheng-Ran Xu*; Single-cell Transcriptomic Analyses of Mouse Pancreatic Endocrine Cells, Journal of Visualized Experiments, 2018.

10. Yu Zhang#, Shuang He#, Xi Wang, Xin Wang, Mao-Yang He, and Xin-Xin Yu, and Cheng-Ran Xu*; ACSS2 mediates an epigenetic pathway to regulate β-cell adaptation during gestation in mice, Nature Communications, 2025.

11. Li Yang#, Xin Wang#, Xin-Xin Yu, Lu Yang, Jing Yang and Cheng-Ran Xu*, The default and directed pathways of bipotent hepatoblast differentiation involve distinct epigenomic mechanisms, Developmental Cell, 2023.

12. Ye Feng#; Wei-Lin Qiu#; Xin-Xin Yu; Yu Zhang; Mao-Yang He; Lin-Chen Li; Li Yang; Weiyi Zhang; Michael Franti; Junqing Ye*; Joerg D. Hoeck*; Cheng-Ran Xu*; Characterizing pancreatic β-cell heterogeneity in the streptozotocin model by single-cell transcriptomic analysis, Molecular Metabolism, 2020.

著作：#共同一作，*通讯作者

Xin-Xin Yu#; Xin Wang#; Wei-Lin Qiu#; Liu Yang; Cheng-Ran Xu*; Pluripotent stem cell therapy for diabetes. Chapter 2: Genetic regulatory networks guiding islet development, Springer Nature, 2024.

科研项目

2021.01-2023.12    国家自然科学基金，青年科学基金项目（现青C），已结题。